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Earth's first and best line of defense is its heroes. For generations, brave men and women have answered the call to protect the world from the villains who threaten its safety and security.

Today, organizations such as VIPER, ARGENT and PSI use both superpowers and super technology in their dastardly plots to control the world. Creatures from outer space and other dimensions seek to enslave humanity. Super scientist Teleios is creating an army of clones and superpowered constructs to do his bidding.

And yet, the greatest threat of all is Doctor Destroyer. A superhuman genius driven to conquer, Destroyer will not stop until all of humanity bends knee to his greatness. In 1992, Destroyer obliterated the city of Detroit and killed thousands. With years to prepare, his next attack is sure to put the entire planet in peril.